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Wednesday, November 15, 2017

Stress, Anxiety and Aging



Medically, it has been established that chronic symptoms of anxiety and stress can crumble our body's immune system. Irrespective of the nature of the causes of stress—real or perceived—our subconscious mind reacts with the same body response by releasing stress hormones equal to the degree of our fear, worry or sense of threat. It brings about changes in the body's biochemical state with extra epinephrine and other adrenal steroids such as hydrocortisone in the bloodstream. It also induces increased palpitation and blood pressure in the body with mental manifestations such as anger, fear, worry or aggression. In short, stress creates anomalies in our body's homeostasis. When the extra chemicals in our bloodstream don't get used up or the stress situation persists, it makes our body prone to mental and physical illnesses.

For example, imagine a secretary in an office. Her boss comes in, angry and furious. He starts blasting the secretary for no apparent reasons. Now, her activated adrenaline cycle would tell her to flee or fight. Her senses become acute, muscles tighten, heartbeats and blood pressure increase and brain activity speeds up. She would probably like to walk out or alternatively, turn around and punch him in the face. But she does neither, for to do so might mean losing her job. So what follows? She burns up a lot of her body energy without achieving anything. At the end of the day she would be left mentally, physically and emotionally exhausted—classic symptoms of anxiety and stress. It can happen to anybody from a high profile businessman to a student, an executive or a homemaker. All are burning out their energies to defend themselves from their real or perceived causes of stress.

New medical research has established that prenatal stress could significantly influence development of the brain and organization of behavior in fetus.

Researchers explain that because stress affects many of the body's systems— nervous, cardiovascular, endocrine and immune— there is good reason to believe that severe emotional stress could cause defects in the fetus, especially during the first trimester of pregnancy when development occurs at the fastest rate.

In women who are exposed to severe stress and anxiety, this effect is caused by reduced blood flow through the arteries that feed the uterus. Usually, the cranial nerve crest, a structure of cells that is thought to contribute to the development of the head and face in a fetus, gets affected.

According to Dr Vivette Glover, research head of a study linking obstetrics, pediatrics, psychology and psychiatry, experiment on animals shows that maternal, fetal, or neonatal experience can set the stress responses of the developing offspring for life. If true, in human beings this could predispose children to have behavioral problems, such as hyperactivity, or cause them to suffer from depression in later life.  

Aging is a natural and gradual process, except under extreme circumstances such as stress or grief. The constant stressors or stress conditions result in a loss in neural and hormonal balance. This loss of balance will cause increased oxidative damage accelerating aging in our body. That's because, chronic disturbances in body homeostasis ultimately affect our hormone secreting glands, cell repair and collagen in our skin and connecting tissues. Immune and neural degenerative diseases prevent this otherwise inevitable process from following the normal and healthy course of events.

Recent research results suggest that long-term exposure to adrenal stress hormones may boost brain aging in later life.

Scientists at the University of Kentucky in Lexington looked at the results of memory tests taken by elderly patients with high levels of the stress hormone cortisol, released by adrenal glands when the body is stressed. That high-level group scored lower than others with reduced levels of the hormone, researchers say.

The level of hormone released apparently affects the total volume of the brain's hippocampus—a major source of recall and memory function, in later life. Researchers found those with high levels of hormone release, had a hippocampus volume 14 per cent less than those with lower levels.

The study results suggest that, "chronic stress may accelerate hippocampal deterioration" leading to accelerated physical and brain aging. 
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